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An approach to the etiology of metabolic syndrome.

ABSTRACT: Increased prevalence of obesity in the world, especially accumulation of abnormal amounts of visceral fat predisposes to insulin resistance, which is the central role of metabolic syndrome (MS). Obesity can deregulate the intracellular signaling of insulin due to the production of inflammatory substances, chemoattractant proteins, adipokines and molecules that trigger hormonal mediator potentials for destabilization of signal transduction, leading to metabolic disorders such as hyperglycemia, hypertension, and dyslipidemia. The complexity of the MS and of the genetic mechanisms involved in its etiology derives from the combination of variants on genes involved and environmental factors that predispose it. The purpose of this paper is to review the effects of obesity in molecular and biochemical responses that trigger insulin resistance and its relation to some candidate genes and the ancestral component of the population.

SUBMITTER: Munoz Contreras AM

PROVIDER: S-EPMC4002015 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature

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An approach to the etiology of metabolic syndrome.

Muñoz Contreras Angélica M AM Bedoya Berrío Gabriel G Velásquez R Claudia M CM

Colombia medica (Cali, Colombia) 20130101 1

Increased prevalence of obesity in the world, especially accumulation of abnormal amounts of visceral fat predisposes to insulin resistance, which is the central role of metabolic syndrome (MS). Obesity can deregulate the intracellular signaling of insulin due to the production of inflammatory substances, chemoattractant proteins, adipokines and molecules that trigger hormonal mediator potentials for destabilization of signal transduction, leading to metabolic disorders such as hyperglycemia, hy ...[more]

PMID: 24892324

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Project description:Background:The objective of this study was to utilize a human-centered approach in designing a diet app that would assist in management of patients with metabolic syndrome. Methods:A convenience sample of 10 dietetic interns (DIs) who were attending their informatics rotation at the City University of New York School of Public Health and Health Policy (CUNY GSPHHP) were recruited during October 2017. The study was conducted in two phases. In phase 1, the DIs received a tutorial on the use of human-centered approach in designing mobile health applications. In phase 2, the DIs were provided a case study for which they designed an app for patients to manage metabolic syndrome using a human centered approach. The goal of phase 2 was to identify the features that were believed to be most important when designing this metabolic syndrome app. An initial questionnaire was administered to the DIs to gather information on their socio-demographics, prior training in nutrition, smart phone usage, perceptions about food logs, and calorie intake calculations. Subsequent questionnaires gathered information from the DIs on their preferred diet app components, app features, rankings of the features, and mock representations of the diet app with the selected features. Results:The DIs were enrolled in the supervised practice component of their training to be Registered Dietitian Nutritionists (RDNs). Fifty percent of them had previously worked in a nutrition-related field. One-third of them were currently using a nutrition app. The top five features of the proposed diet app which the DIs identified as very important included (I) personalization of the app based on user preferences (80%, n=8); (II) disease specific education tips (90%, n=9); (III) ability to track progress (80%; n=8); (IV) reminders (70%, n=7) and (V) reinforcement based on user feedback (50%, n=5). In translating the identified features into functional requirements, majority of the DIs felt that the five key features identified should incorporate the following components: (I) personalization of the app should comprise information on medical factors, personal information, personal preferences, and recording weights; (II) disease specific educational tips should comprise information on food selections, low sodium options, and recipes for diabetes; (III) tracking progress should comprise features for storing audio files, viewing previous logs and uploading photos into a library; (IV) reminders should comprise daily messages to the users from the app; and (V) reinforcement should comprise provisions to enter motivational messages. Conclusions:Our study lends support to the need for utilizing human-centered design (HCD) approaches in developing e-health dietary apps as well other non-diet related apps. App developers are encouraged to incorporate user characteristics, needs and preferences using a HCD framework that will allow for reproducibility, tailoring, user satisfaction, and effectiveness assessments.

Dataset Information

An approach to the etiology of metabolic syndrome.

Publications

An approach to the etiology of metabolic syndrome.

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