Ontology highlight
ABSTRACT:
SUBMITTER: Ewens CA
PROVIDER: S-EPMC4002113 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Ewens Caroline A CA Panico Silvia S Kloppsteck Patrik P McKeown Ciaran C Ebong Ima-Obong IO Robinson Carol C Zhang Xiaodong X Freemont Paul S PS
The Journal of biological chemistry 20140311 17
p97, also known as valosin-containing protein, is a versatile participant in the ubiquitin-proteasome system. p97 interacts with a large network of adaptor proteins to process ubiquitylated substrates in different cellular pathways, including endoplasmic reticulum-associated degradation and transcription factor activation. p97 and its adaptor Fas-associated factor-1 (FAF1) both have roles in the ubiquitin-proteasome system during NF-κB activation, although the mechanisms are unknown. FAF1 itself ...[more]