Ontology highlight
ABSTRACT:
SUBMITTER: Liao ZQ
PROVIDER: S-EPMC4002130 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Liao Zong-Quan ZQ Dong Chune C Carlson Kathryn E KE Srinivasan Sathish S Nwachukwu Jerome C JC Chesnut Robert W RW Sharma Abhishek A Nettles Kendall W KW Katzenellenbogen John A JA Zhou Hai-Bing HB
Journal of medicinal chemistry 20140407 8
We have explored the isoelectronic replacement of the C═C double bond found at the core of many nonsteroidal estrogen ligands with a simple Schiff base (C═N). Di- and triaryl-substituted imine derivatives were conveniently prepared by the condensation of benzophenones with various anilines without the need for phenolic hydroxy protection. Most of these imines demonstrated high affinity for the estrogen receptors, which, in some cases exceeded that of estradiol. In cell-based assays, these imines ...[more]