Ontology highlight
ABSTRACT:
SUBMITTER: Schaab C
PROVIDER: S-EPMC4234217 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Schaab Carolin C Kling Ralf Christian RC Einsiedel Jürgen J Hübner Harald H Clark Tim T Seebach Dieter D Gmeiner Peter P
ChemistryOpen 20140923 5
Subtype-selective agonists of the neurotensin receptor NTS2 represent a promising option for the treatment of neuropathic pain, as NTS2 is involved in the mediation of μ-opioid-independent anti-nociceptive effects. Based on the crystal structure of the subtype NTS1 and previous structure-activity relationships (SARs) indicating a potential role for the sub-pocket around Tyr11 of NT(8-13) in subtype-specific ligand recognition, we have developed new NTS2-selective ligands. Starting from NT(8-13), ...[more]