Ontology highlight
ABSTRACT:
SUBMITTER: Zheng XQ
PROVIDER: S-EPMC4002670 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Zheng X Q XQ Guo J P JP Yang H H Kanai M M He L L LL Li Y Y YY Koomen J M JM Minton S S Gao M M Ren X B XB Coppola D D Cheng J Q JQ
Oncogene 20131028 42
Despite the clinical success of tamoxifen, its resistance remains a major challenge in breast cancer. Here we show that Aurora-A determines tamoxifen sensitivity by regulation of oestrogen receptor (ER)α. Ectopic expression of Aurora-A decreases and depletion of Aurora-A enhances tamoxifen sensitivity in ERα-positive breast cancer. Elevated Aurora-A was significantly associated with the recurrence of ERα-positive tumours. Notably, Aurora-A inhibitor MLN8237, which is currently in clinical trial, ...[more]