Ontology highlight
ABSTRACT:
SUBMITTER: Opyrchal M
PROVIDER: S-EPMC4016211 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Opyrchal Mateusz M Salisbury Jeffrey L JL Zhang Shuya S McCubrey James J Hawse John J Goetz Mattew P MP Lomberk Gwen A GA Haddad Tufia T Degnim Amy A Lange Carol C Ingle James N JN Galanis Evanthia E D'Assoro Antonino B AB
PloS one 20140509 5
Development of endocrine resistance during tumor progression represents a major challenge in the management of estrogen receptor alpha (ERα) positive breast tumors and is an area under intense investigation. Although the underlying mechanisms are still poorly understood, many studies point towards the 'cross-talk' between ERα and MAPK signaling pathways as a key oncogenic axis responsible for the development of estrogen-independent growth of breast cancer cells that are initially ERα+ and hormon ...[more]