Ontology highlight
ABSTRACT:
SUBMITTER: Lesman A
PROVIDER: S-EPMC4003238 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Lesman Ayelet A Notbohm Jacob J Tirrell David A DA Ravichandran Guruswami G
The Journal of cell biology 20140401 2
Physical forces direct the orientation of the cell division axis for cells cultured on rigid, two-dimensional (2D) substrates. The extent to which physical forces regulate cell division in three-dimensional (3D) environments is not known. Here, we combine live-cell imaging with digital volume correlation to map 3D matrix displacements and identify sites at which cells apply contractile force to the matrix as they divide. Dividing cells embedded in fibrous matrices remained anchored to the matrix ...[more]