Ontology highlight
ABSTRACT:
SUBMITTER: Sevinsky JR
PROVIDER: S-EPMC400447 | biostudies-literature | 2004 May
REPOSITORIES: biostudies-literature
Sevinsky Joel R JR Whalen Anne M AM Ahn Natalie G NG
Molecular and cellular biology 20040501 10
Extracellular signal-regulated kinase (ERK) facilitates cell cycle progression in most mammalian cells, but in certain cell types prolonged signaling through this pathway promotes differentiation and lineage-specific gene expression through mechanisms that are poorly understood. Here, we characterize the transcriptional regulation of platelet GPIIb integrin (CD41) by ERK during megakaryocyte differentiation. ERK-dependent transactivation involves the proximal promoter of GPIIb within 114 bp upst ...[more]