Ontology highlight
ABSTRACT:
SUBMITTER: Hwang CY
PROVIDER: S-EPMC2698740 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Hwang Chae Young CY Lee Cheolju C Kwon Ki-Sun KS
Molecular and cellular biology 20090413 12
p21(Cip1) is an inhibitor of cell cycle progression that promotes G(1)-phase arrest by direct binding to cyclin-dependent kinase and proliferating cell nuclear antigen. Here we demonstrate that mitogenic stimuli, such as epidermal growth factor treatment and oncogenic Ras transformation, induce p21(Cip1) downregulation at the posttranslational level. This downregulation requires the sustained activation of extracellular signal-regulated kinase 2 (ERK2), which directly interacts with and phosphor ...[more]