Toll-like receptor genetic variants and colorectal cancer.
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ABSTRACT:
SUBMITTER: Weber AN
PROVIDER: S-EPMC4004619 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Publications
Toll-like receptor genetic variants and colorectal cancer.
Weber Alexander Nr AN Försti Asta A
Oncoimmunology 20140110 1
Single-nucleotide polymorphisms in Toll-like receptor 5 (<i>TLR5</i>), encoding a sensor for flagellin, have been shown to influence cytokine responses to intestinal bacteria and to be associated with significant alterations in the survival of colorectal carcinoma (CRC) patients. These findings point to a link between TLRs and CRC that may have both therapeutic and prognostic/predictive implications. ...[more]
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