Ontology highlight
ABSTRACT:
SUBMITTER: Chaly Y
PROVIDER: S-EPMC4004659 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Chaly Yury Y Fu Yu Y Marinov Anthony A Hostager Bruce B Yan Wei W Campfield Brian B Kellum John A JA Bushnell Daniel D Wang Yudong Y Vockley Jerry J Hirsch Raphael R
European journal of immunology 20140220 5
Follistatin-like protein 1 (FSTL-1) is overexpressed in a number of inflammatory conditions characterized by elevated IL-1β. Here, we found that FSTL-1 serum concentration was increased threefold in patients with bacterial sepsis and fourfold following administration of LPS to mice. To test the contribution of FSTL-1 to IL-1β secretion, WT and FSTL-1-deficient mice were injected with LPS. While LPS induced IL-1β in the sera of WT mice, it was low or undetectable in FSTL-1-deficient mice. Monocyt ...[more]