Ontology highlight
ABSTRACT:
SUBMITTER: Diaz-Del-Olmo I
PROVIDER: S-EPMC8506164 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Diaz-Del-Olmo Ines I Worboys Jonathan J Martin-Sanchez Fatima F Gritsenko Anna A Ambrose Ashley R AR Tannahill Gillian M GM Nichols Eva-Maria EM Lopez-Castejon Gloria G Davis Daniel M DM
Frontiers in immunology 20210928
Interleukin 1β (IL-1β) plays a major role in inflammation and is secreted by immune cells, such as macrophages, upon recognition of danger signals. Its secretion is regulated by the inflammasome, the assembly of which results in caspase 1 activation leading to gasdermin D (GSDMD) pore formation and IL-1β release. During inflammation, danger signals also activate the complement cascade, resulting in the formation of the membrane attack complex (MAC). Here, we report that stimulation of LPS-primed ...[more]