Ontology highlight
ABSTRACT:
SUBMITTER: Eilebrecht S
PROVIDER: S-EPMC4005653 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Eilebrecht Sebastian S Le Douce Valentin V Riclet Raphael R Targat Brice B Hallay Houda H Van Driessche Benot B Schwartz Christian C Robette Gwenaëlle G Van Lint Carine C Rohr Olivier O Benecke Arndt G AG
Nucleic acids research 20140311 8
Active positive transcription elongation factor b (P-TEFb) is essential for cellular and human immunodeficiency virus type 1 (HIV-1) transcription elongation. CTIP2 represses P-TEFb activity in a complex containing 7SK RNA and HEXIM1. Recently, the inactive 7SK/P-TEFb small nuclear RNP (snRNP) has been detected at the HIV-1 core promoter as well as at the promoters of cellular genes, but a recruiting mechanism still remains unknown to date. Here we show global synergy between CTIP2 and the 7SK-b ...[more]