Ontology highlight
ABSTRACT:
SUBMITTER: Forouzanfar F
PROVIDER: S-EPMC6739472 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Scientific reports 20190911 1
Mammals have evolved many antiviral factors impacting different steps of the viral life cycle. Associated with chromatin-modifying enzymes, the cellular cofactor CTIP2 contributes to HIV-1 gene silencing in latently infected reservoirs that constitute the major block toward an HIV cure. We report, for the first time, that the virus has developed a strategy to overcome this major transcriptional block. Productive HIV-1 infection results in a Vpr-mediated depletion of CTIP2 in microglial cells and ...[more]