Ontology highlight
ABSTRACT:
SUBMITTER: Convertini P
PROVIDER: S-EPMC4005683 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Convertini Paolo P Shen Manli M Potter Philip M PM Palacios Gustavo G Lagisetti Chandraiah C de la Grange Pierre P Horbinski Craig C Fondufe-Mittendorf Yvonne N YN Webb Thomas R TR Stamm Stefan S
Nucleic acids research 20140311 8
Sudemycin E is an analog of the pre-messenger RNA splicing modulator FR901464 and its derivative spliceostatin A. Sudemycin E causes the death of cancer cells through an unknown mechanism. We found that similar to spliceostatin A, sudemycin E binds to the U2 small nuclear ribonucleoprotein (snRNP) component SF3B1. Native chromatin immunoprecipitations showed that U2 snRNPs physically interact with nucleosomes. Sudemycin E induces a dissociation of the U2 snRNPs and decreases their interaction wi ...[more]