Ontology highlight
ABSTRACT:
SUBMITTER: Bastos-Aristizabal S
PROVIDER: S-EPMC4005713 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Bastos-Aristizabal Sara S Kozlov Guennadi G Gehring Kalle K
Protein science : a publication of the Protein Society 20140311 5
Protein disulfide isomerases (PDIs) are responsible for catalyzing the proper oxidation and isomerization of disulfide bonds of newly synthesized proteins in the endoplasmic reticulum (ER). Here, it is shown that human PDI (PDIA1) dimerizes in vivo and proposed that the dimerization of PDI has physiological relevance by autoregulating its activity. The crystal structure of the dimeric form of noncatalytic bb' domains of human PDIA1 determined to 2.3 Å resolution revealed that the formation of di ...[more]