Ontology highlight
ABSTRACT:
SUBMITTER: Pereira FV
PROVIDER: S-EPMC4005744 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Pereira Felipe V FV Ferreira-Guimarães Carla A CA Paschoalin Thaysa T Scutti Jorge A B JA Melo Filipe M FM Silva Luis S LS Melo Amanda C L AC Silva Priscila P Tiago Manoela M Matsuo Alisson L AL Juliano Luiz L Juliano Maria A MA Carmona Adriana K AK Travassos Luiz R LR Rodrigues Elaine G EG
PloS one 20140430 4
The increased incidence, high rates of mortality and few effective means of treatment of malignant melanoma, stimulate the search for new anti-tumor agents and therapeutic targets to control this deadly metastatic disease. In the present work the antitumor effect of arazyme, a natural bacterial-derived metalloprotease secreted by Serratia proteomaculans, was investigated. Arazyme significantly reduced the number of pulmonary metastatic nodules after intravenous inoculation of B16F10 melanoma cel ...[more]