Ontology highlight
ABSTRACT:
SUBMITTER: Lynagh T
PROVIDER: S-EPMC4006026 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Lynagh Timothy T Pless Stephan A SA
Frontiers in physiology 20140424
Cys-loop receptors are ligand-gated ion channels that are activated by a structurally diverse array of neurotransmitters, including acetylcholine, serotonin, glycine, and GABA. After the term "chemoreceptor" emerged over 100 years ago, there was some wait until affinity labeling, molecular cloning, functional studies, and X-ray crystallography experiments identified the extracellular interface of adjacent subunits as the principal site of agonist binding. The question of how subtle differences a ...[more]