The desensitization gate of inhibitory Cys-loop receptors.
Ontology highlight
ABSTRACT:
SUBMITTER: Gielen M
PROVIDER: S-EPMC4410641 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Publications
The desensitization gate of inhibitory Cys-loop receptors.
Gielen Marc M Thomas Philip P Smart Trevor G TG
Nature communications 20150420
Cys-loop neurotransmitter-gated ion channels are vital for communication throughout the nervous system. Following activation, these receptors enter into a desensitized state in which the ion channel shuts even though the neurotransmitter molecules remain bound. To date, the molecular determinants underlying this most fundamental property of Cys-loop receptors have remained elusive. Here we present a generic mechanism for the desensitization of Cys-loop GABAA (GABAARs) and glycine receptors (GlyR ...[more]
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