Ontology highlight
ABSTRACT:
SUBMITTER: Sandoval GJ
PROVIDER: S-EPMC4006353 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Sandoval Gabriel J GJ Graham Daniel B DB Gmyrek Grzegorz B GB Akilesh Holly M HM Fujikawa Keiko K Sammut Benedicte B Bhattacharya Deepta D Srivatsan Shuba S Kim Alfred A Shaw Andrey S AS Yang-Iott Katherine K Bassing Craig H CH Duncavage Eric E Xavier Ramnik J RJ Swat Wojciech W
Cancer immunology research 20131007 6
Drosophila melanogaster discs large (dlg) is an essential tumor suppressor gene (TSG) controlling epithelial cell growth and polarity of the fly imaginal discs in pupal development. A mammalian ortholog, Dlg1, is involved in embryonic urogenital morphogenesis, postsynaptic densities in neurons, and immune synapses in lymphocytes. However, a potential role for Dlg1 as a mammalian TSG is unknown. Here, we present evidence that loss of Dlg1 confers strong predisposition to the development of malign ...[more]