Mechanism of Ikaros tumor suppression in Leukemia
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: chunhua song
PROVIDER: E-GEOD-44218 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia.
Song Chunhua C Gowda Chandrika C Pan Xiaokang X Ding Yali Y Tong Yongqing Y Tan Bi-Hua BH Wang Haijun H Muthusami Sunil S Ge Zheng Z Sachdev Mansi M Amin Shantu G SG Desai Dhimant D Gowda Krishne K Gowda Raghavendra R Robertson Gavin P GP Schjerven Hilde H Muschen Markus M Payne Kimberly J KJ Dovat Sinisa S
Blood 20150728 15
Ikaros (IKZF1) is a tumor suppressor that binds DNA and regulates expression of its target genes. The mechanism of Ikaros activity as a tumor suppressor and the regulation of Ikaros function in leukemia are unknown. Here, we demonstrate that Ikaros controls cellular proliferation by repressing expression of genes that promote cell cycle progression and the phosphatidylinositol-3 kinase (PI3K) pathway. We show that Ikaros function is impaired by the pro-oncogenic casein kinase II (CK2), and that ...[more]
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