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Structure of the activating IL-1 receptor signaling complex.

ABSTRACT: Interleukin-1 (IL-1)-family cytokines are mediators of innate and adaptive immunity. They exert proinflammatory effects by binding a primary receptor that recruits a receptor accessory protein to form a signaling-competent heterotrimeric complex. Here we present the crystal structure of IL-1? bound to its primary receptor IL-1RI and its receptor accessory protein IL-1RAcP, providing insight into how IL-1-type cytokines initiate signaling and revealing an evolutionary relationship with the fibroblast growth factor receptor family.

SUBMITTER: Thomas C

PROVIDER: S-EPMC4006550 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature

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Structure of the activating IL-1 receptor signaling complex.

Thomas Christoph C Bazan J Fernando JF Garcia K Christopher KC

Nature structural & molecular biology 20120318 4

Interleukin-1 (IL-1)-family cytokines are mediators of innate and adaptive immunity. They exert proinflammatory effects by binding a primary receptor that recruits a receptor accessory protein to form a signaling-competent heterotrimeric complex. Here we present the crystal structure of IL-1β bound to its primary receptor IL-1RI and its receptor accessory protein IL-1RAcP, providing insight into how IL-1-type cytokines initiate signaling and revealing an evolutionary relationship with the fibrob ...[more]

PMID: 22426547

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