Ontology highlight
ABSTRACT:
SUBMITTER: Yano T
PROVIDER: S-EPMC4006628 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Circulation research 20140220 8
<h4>Rationale</h4>There is tight coupling between Akt activation and suppression of cell death. Full Akt activation requires mammalian target of rapamycin complex 2 (mTORC2), but the regulation of mTORC2 is unclear.<h4>Objective</h4>To gain new insights into mechanisms of mTORC2/Akt signaling.<h4>Methods and results</h4>The role of mTORC2 in cardioprotection was examined. In perfused mouse hearts, ischemic preconditioning increased mTORC2 activity, leading to phosphorylation of Akt on Ser473. Th ...[more]