Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC4007184 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Zhang Xu X Zhou Yang Y Shen Yu Y Du Li-li LL Chen Jun-hua JH Leng Ying Y Shen Jian-hua JH
Acta pharmacologica Sinica 20090824 9
<h4>Aim</h4>To design and synthese a novel class of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitors, featuring the (phenylsulfonamido-methyl)pyridine and (phenylsulfonamido-methyl)thiazole framework.<h4>Methods</h4>Our initial lead 4-(phenylsulfonamido-methyl)benzamides were modified. Inhibition of human and mouse 11beta-HSD1 enzymatic activities by the new compounds was determined by a scintillation proximity assay (SPA) using microsomes containing 11beta-HSD1.<h4>Results</h ...[more]