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Synthesis and evaluation of cholecystokinin trimers: a multivalent approach to pancreatic cancer detection and treatment.

ABSTRACT: In the quest for novel tools for early detection and treatment of cancer, we propose the use of multimers targeting overexpressed receptors at the cancer cell surface. Indeed, multimers are prone to create multivalent interactions, more potent and specific than their corresponding monovalent versions, thus enabling the potential for early detection. There is a lack of tools for early detection of pancreatic cancer, one of the deadliest forms of cancer, but CCK2-R overexpression on pancreatic cancer cells makes CCK based multimers potential markers for these cells. In this Letter, we describe the synthesis and evaluation of CCK trimers targeting overexpressed CCK2-R.

SUBMITTER: Brabez N

PROVIDER: S-EPMC4007200 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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Synthesis and evaluation of cholecystokinin trimers: a multivalent approach to pancreatic cancer detection and treatment.

Brabez Nabila N Nguyen Kevin L KL Saunders Kara K Lacy Ryan R Xu Liping L Gillies Robert J RJ Lynch Ronald M RM Chassaing Gerard G Lavielle Solange S Hruby Victor J VJ

Bioorganic & medicinal chemistry letters 20130213 8

In the quest for novel tools for early detection and treatment of cancer, we propose the use of multimers targeting overexpressed receptors at the cancer cell surface. Indeed, multimers are prone to create multivalent interactions, more potent and specific than their corresponding monovalent versions, thus enabling the potential for early detection. There is a lack of tools for early detection of pancreatic cancer, one of the deadliest forms of cancer, but CCK2-R overexpression on pancreatic can ...[more]

PMID: 23489620

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