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A tissue-specific gene expression template portrays heart development and pathology.

ABSTRACT: Congenital heart defects (CHD) are the most common cause of death in children under the age of 1. Tetralogy of Fallot (TOF) is a severe CHD that results from developmental defects in the conotruncal outflow tract. Recently, a tissue-specific gene expression template (GET) was derived from microarray data that accurately characterized multiple normal human tissues. We used the GET to examine spatial, temporal, and a pathological condition (TOF) within a single organ, the heart. The GET, as previously defined, generally identified temporal and spatial differences in the cardiac tissue. Differences in the stoichiometry of the GET reflected the severe developmental disturbance associated with TOF. Our analysis suggests that the homoeostatic equilibrium assessed by the GET at the inter-organ level is generally maintained at the intra-organ level as well.

SUBMITTER: Rodemoyer A

PROVIDER: S-EPMC4007492 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

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A tissue-specific gene expression template portrays heart development and pathology.

Rodemoyer Amy A Kibiryeva Nataliya N Bair Alexis A Marshall Jennifer J O'Brien James E JE Bittel Douglas C DC

Human genomics 20140311

Congenital heart defects (CHD) are the most common cause of death in children under the age of 1. Tetralogy of Fallot (TOF) is a severe CHD that results from developmental defects in the conotruncal outflow tract. Recently, a tissue-specific gene expression template (GET) was derived from microarray data that accurately characterized multiple normal human tissues. We used the GET to examine spatial, temporal, and a pathological condition (TOF) within a single organ, the heart. The GET, as previo ...[more]

PMID: 24618031

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A tissue-specific gene expression template portrays heart development and pathology.

Publications

A tissue-specific gene expression template portrays heart development and pathology.

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