Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Endomitosis controls tissue-specific gene expression during development

ABSTRACT: Endomitosis controls tissue-specific gene expression during development

PROVIDER: PRJNA716284 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR14034349_1.fastq.gz	Fastqsanger.gz
	SRR14034349_2.fastq.gz	Fastqsanger.gz
	SRR14034350_1.fastq.gz	Fastqsanger.gz
	SRR14034350_2.fastq.gz	Fastqsanger.gz
	SRR14034351_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 32

Similar Datasets

Gastrointestinal tissue-specific chromatin accessibility and gene expression during development

Project description:Gastrointestinal tissue-specific chromatin accessibility and gene expression during development

| PRJNA554630 | ENA

Progressing super-enhancer landscape during mammary differentiation controls tissue-specific gene regulation

Project description:Progressing super-enhancer landscape during mammary differentiation controls tissue-specific gene regulation

| PRJNA474722 | ENA

Endomitosis controls tissue-specific gene expression during development

Project description:Polyploid cells contain more than two copies of the genome and are found in many plant and animal tissues. Different types of polyploidy exist, in which the genome is confined to either one nucleus (mononucleation) or two or more nuclei (multinucleation). Despite the widespread occurrence of polyploidy, the functional significance of different types of polyploidy are largely unknown. Here, we assess the function of multinucleation in C. elegans intestinal cells through specific inhibition of binucleation without altering genome ploidy. Through single worm RNA sequencing, we find that binucleation is important for tissue-specific gene expression, most prominently for genes that show a rapid upregulation at the transition from larval development to adulthood. Regulated genes include vitellogenins, which encode yolk proteins that facilitate nutrient transport to the germline. We find that reduced expression of vitellogenins in mononucleated intestinal cells leads to progeny with developmental delays and reduced fitness. Together, our results show that binucleation facilitates rapid upregulation of intestine-specific gene expression during development, independently of genome ploidy, underscoring the importance of spatial genome organization for polyploid cell function.

2022-03-07 | GSE169330 | GEO

Gastrointestinal tissue-specific chromatin accessibility and gene expression during development (ChIP-seq)

Project description:Gastrointestinal tissue-specific chromatin accessibility and gene expression during development (ChIP-seq)

| PRJNA555624 | ENA

Gastrointestinal tissue-specific chromatin accessibility and gene expression during development (RNA-Seq)

Project description:Gastrointestinal tissue-specific chromatin accessibility and gene expression during development (RNA-Seq)

| PRJNA554635 | ENA

Gastrointestinal tissue-specific chromatin accessibility and gene expression during development (ATAC-Seq)

Project description:Gastrointestinal tissue-specific chromatin accessibility and gene expression during development (ATAC-Seq)

| PRJNA554634 | ENA

Genome organization controls transcriptional dynamics during development

Project description:Genome organization controls transcriptional dynamics during development