Ontology highlight
ABSTRACT:
SUBMITTER: Lin Z
PROVIDER: S-EPMC4007576 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Lin Zhenghong Z Yang Heeyoung H Tan Can C Li Jinping J Liu Zhaojian Z Quan Qiu Q Kong Sinyi S Ye Junsheng J Gao Beixue B Fang Deyu D
Cell reports 20131212 6
The reduced protein expression of SIRT6 tumor suppressor is involved in tumorigenesis. The molecular mechanisms underlying SIRT6 protein downregulation in human cancers remain unknown. Using a proteomic approach, we have identified the ubiquitin-specific peptidase USP10, another tumor suppressor, as one of the SIRT6-interacting proteins. USP10 suppresses SIRT6 ubiquitination to protect SIRT6 from proteasomal degradation. USP10 antagonizes the transcriptional activity of the c-Myc oncogene throug ...[more]