Ontology highlight
ABSTRACT:
SUBMITTER: Ko A
PROVIDER: S-EPMC5988833 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Cell death and differentiation 20180222 6
Oncogene-induced senescence (OIS) is a critical tumor-suppressor mechanism, which prevents hyper-proliferation and transformation of cells. c-Myc promotes OIS through the transcriptional activation of p14ARF followed by p53 activation. Although the oncogene-mediated transcriptional regulation of p14ARF has been well addressed, the post-translational modification of p14ARF regulated by oncogenic stress has yet to be investigated. Here, we found that c-Myc increased p14ARF protein stability by ind ...[more]