Vorinostat-like molecules as structural, stereochemical, and pharmacological tools.
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ABSTRACT:
SUBMITTER: Hanessian S
PROVIDER: S-EPMC4007911 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Publications
Vorinostat-like molecules as structural, stereochemical, and pharmacological tools.
Hanessian Stephen S Auzzas Luciana L Larsson Andreas A Zhang Jianbin J Giannini Giuseppe G Gallo Grazia G Ciacci Andrea A Cabri Walter W
ACS medicinal chemistry letters 20100311 2
The inhibitory activity of an ω-alkoxy analogue of the HDAC inhibitor, Vorinostat (SAHA), against the 11 isoforms of HDAC is described and evaluated with regard to structural biology information retrieved through computational methods. Preliminary absorption and metabolism studies were performed, which positioned this compound as a potential candidate for further preclinical studies and delineated measures for improving its pharmacokinetic profile. ...[more]
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