Ontology highlight
ABSTRACT:
SUBMITTER: Wang F
PROVIDER: S-EPMC4575645 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Wang Fengbin F Singh Shanteri S Xu Weijun W Helmich Kate E KE Miller Mitchell D MD Cao Hongnan H Bingman Craig A CA Thorson Jon S JS Phillips George N GN
ACS chemical biology 20150623 9
Sugar aminotransferases (SATs) are an important class of tailoring enzymes that catalyze the 5'-pyridoxal phosphate (PLP)-dependent stereo- and regiospecific installation of an amino group from an amino acid donor (typically L-Glu or L-Gln) to a corresponding ketosugar nucleotide acceptor. Herein we report the strategic structural study of two homologous C4 SATs (Micromonospora echinospora CalS13 and Escherichia coli WecE) that utilize identical substrates but differ in their stereochemistry of ...[more]