Ontology highlight
ABSTRACT:
SUBMITTER: Bonifazi F
PROVIDER: S-EPMC4007922 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Bonifazi Francesca F Storci Gianluca G Bandini Giuseppe G Marasco Elena E Dan Elisa E Zani Elena E Albani Fiorenzo F Bertoni Sara S Bontadini Andrea A De Carolis Sabrina S Sapienza Maria Rosaria MR Rizzi Simonetta S Motta Maria Rosa MR Ferioli Martina M Garagnani Paolo P Cavo Michele M Mantovani Vilma V Bonafè Massimiliano M
Haematologica 20130920 1
Busulfan liver metabolism depends on glutathione, a crucial mediator of cellular and systemic stress. Here we investigated 40 polymorphisms at 27 loci involved in hepatic glutathione homeostasis, with the aim of testing their impact on the clinical outcome of 185 busulfan-conditioned allogeneic transplants. GSTA2 S112T serine allele homozygosity is an independent prognostic factor for poorer survival (RR=2.388), for increased any time- and 100-day transplant-related mortality (RR=4.912 and RR=5. ...[more]