Ontology highlight
ABSTRACT:
SUBMITTER: Yoon C
PROVIDER: S-EPMC4008324 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Yoon Christina C Subramanian Anuradha A Chi Amy A Crothers Kristina K Meshnick Steven R SR Taylor Steve M SM Beard Charles B CB Jarlsberg Leah G LG Lawrence Gena G GG Avery Melissa M Swartzman Alexandra A Fong Serena S Roth Brenna B Huang Laurence L
Medical mycology 20130308 6
Pneumocystis jirovecii dihydropteroate synthase (DHPS) gene mutations are well-reported. Although sulfa prophylaxis generally is associated with DHPS mutant infection, whether mutant infection is associated with poorer clinical outcomes is less clear. The differing definitions of sulfa prophylaxis and the different mortality endpoints used in these studies may be one explanation for the conflicting study results. Applying different definitions of prophylaxis, mortality endpoints and DHPS mutant ...[more]