Ontology highlight
ABSTRACT:
SUBMITTER: Sawa-Makarska J
PROVIDER: S-EPMC4009068 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Sawa-Makarska Justyna J Abert Christine C Romanov Julia J Zens Bettina B Ibiricu Iosune I Martens Sascha S
Nature cell biology 20140406 5
Autophagy protects cells from harmful substances such as protein aggregates, damaged mitochondria and intracellular pathogens, and has been implicated in a variety of diseases. Selectivity of autophagic processes is mediated by cargo receptors that link cargo to Atg8 family proteins on the developing autophagosomal membrane. To avoid collateral degradation during constitutive autophagic pathways, the autophagic machinery must not only select cargo but also exclude non-cargo material. Here we sho ...[more]