Ontology highlight
ABSTRACT:
SUBMITTER: Abreu S
PROVIDER: S-EPMC5412903 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Abreu Susana S Kriegenburg Franziska F Gómez-Sánchez Rubén R Mari Muriel M Sánchez-Wandelmer Jana J Skytte Rasmussen Mads M Soares Guimarães Rodrigo R Zens Bettina B Schuschnig Martina M Hardenberg Ralph R Peter Matthias M Johansen Terje T Kraft Claudine C Martens Sascha S Reggiori Fulvio F
EMBO reports 20170322 5
Deconjugation of the Atg8/LC3 protein family members from phosphatidylethanolamine (PE) by Atg4 proteases is essential for autophagy progression, but how this event is regulated remains to be understood. Here, we show that yeast Atg4 is recruited onto autophagosomal membranes by direct binding to Atg8 via two evolutionarily conserved Atg8 recognition sites, a classical LC3-interacting region (LIR) at the C-terminus of the protein and a novel motif at the N-terminus. Although both sites are impor ...[more]