Ontology highlight
ABSTRACT:
SUBMITTER: Huang T
PROVIDER: S-EPMC4009703 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Huang Tingting T Rivera-Pérez Jaime A JA
Genesis (New York, N.Y. : 2000) 20140328 4
Senescence-associated β-galactosidase (SA-β-gal) activity is widely used as a marker of cellular senescence and as an indicator of organismal aging. Here, we report that SA-β-gal activity is present in the visceral endoderm layer of early postimplantation mouse embryos in predictable patterns that vary as the embryo progresses in development. However, determination of the mitotic index and analysis of the expression of Cdkn1a (p21), a marker of senescent cells, do not indicate cellular senescenc ...[more]