Senescence-associated-?-galactosidase staining following traumatic brain injury in the mouse cerebrum.
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ABSTRACT:
SUBMITTER: Tominaga T
PROVIDER: S-EPMC6411151 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Senescence-associated-β-galactosidase staining following traumatic brain injury in the mouse cerebrum.
Tominaga Tadasuke T Shimada Ryo R Okada Yoshikazu Y Kawamata Takakazu T Kibayashi Kazuhiko K
PloS one 20190311 3
Primary and secondary traumatic brain injury (TBI) can cause tissue damage by inducing cell death pathways including apoptosis, necroptosis, and autophagy. However, similar pathways can also lead to senescence. Senescent cells secrete senescence-associated secretory phenotype proteins following persistent DNA damage response signaling, leading to cell disorders. TBI initially activates the cell cycle followed by the subsequent triggering of senescence. This study aims to clarify how the mRNA and ...[more]
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