Ontology highlight
ABSTRACT:
SUBMITTER: Prensner JR
PROVIDER: S-EPMC4009928 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Prensner John R JR Chen Wei W Iyer Matthew K MK Cao Qi Q Ma Teng T Han Sumin S Sahu Anirban A Malik Rohit R Wilder-Romans Kari K Navone Nora N Logothetis Christopher J CJ Araujo John C JC Pisters Louis L LL Tewari Ashutosh K AK Canman Christine E CE Knudsen Karen E KE Kitabayashi Naoki N Rubin Mark A MA Demichelis Francesca F Lawrence Theodore S TS Chinnaiyan Arul M AM Feng Felix Y FY
Cancer research 20140128 6
Impairment of double-stranded DNA break (DSB) repair is essential to many cancers. However, although mutations in DSB repair proteins are common in hereditary cancers, mechanisms of impaired DSB repair in sporadic cancers remain incompletely understood. Here, we describe the first role for a long noncoding RNA (lncRNA) in DSB repair in prostate cancer. We identify PCAT-1, a prostate cancer outlier lncRNA, which regulates cell response to genotoxic stress. PCAT-1 expression produces a functional ...[more]