Ontology highlight
ABSTRACT:
SUBMITTER: Mungamuri SK
PROVIDER: S-EPMC4009975 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Mungamuri Sathish Kumar SK Benson Erica Kay EK Wang Shaomeng S Gu Wei W Lee Sam W SW Aaronson Stuart A SA
Nature structural & molecular biology 20120401 5
p53 is a major sensor of cellular stresses, and its activation influences cell fate decisions. We identified SUV39H1, a histone code 'writer' responsible for the histone H3 Lys9 trimethylation (H3K9me3) mark for 'closed' chromatin conformation, as a target of p53 repression. SUV39H1 downregulation was mediated transcriptionally by p21 and post-translationally by MDM2. The H3K9me3 repression mark was found to be associated with promoters of representative p53 target genes and was decreased upon p ...[more]