Ontology highlight
ABSTRACT:
SUBMITTER: Harton MD
PROVIDER: S-EPMC6761572 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Harton Marie D MD Koh Woo Seuk WS Bunker Amie D AD Singh Abhyudai A Batchelor Eric E
Molecular systems biology 20190901 9
The p53 tumor suppressor regulates distinct responses to cellular stresses. Although different stresses generate different p53 dynamics, the mechanisms by which cells decode p53 dynamics to differentially regulate target genes are not well understood. Here, we determined in individual cells how canonical p53 target gene promoters vary in responsiveness to features of p53 dynamics. Employing a chemical perturbation approach, we independently modulated p53 pulse amplitude, duration, or frequency, ...[more]