Ontology highlight
ABSTRACT:
SUBMITTER: Doulias PT
PROVIDER: S-EPMC4010156 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Doulias Paschalis-Thomas PT Tenopoulou Margarita M Greene Jennifer L JL Raju Karthik K Ischiropoulos Harry H
Science signaling 20130101 256
Cysteine S-nitrosylation is a posttranslational modification by which nitric oxide regulates protein function and signaling. Studies of individual proteins have elucidated specific functional roles for S-nitrosylation, but knowledge of the extent of endogenous S-nitrosylation, the sites that are nitrosylated, and the regulatory consequences of S-nitrosylation remains limited. We used mass spectrometry-based methodologies to identify 1011 S-nitrosocysteine residues in 647 proteins in various mous ...[more]