Ontology highlight
ABSTRACT:
SUBMITTER: Lillehoj EP
PROVIDER: S-EPMC4010649 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Lillehoj Erik P EP Hyun Sang Won SW Feng Chiguang C Zhang Lei L Liu Anguo A Guang Wei W Nguyen Chinh C Sun Wenji W Luzina Irina G IG Webb Tonya J TJ Atamas Sergei P SP Passaniti Antonino A Twaddell William S WS Puché Adam C AC Wang Lai-Xi LX Cross Alan S AS Goldblum Simeon E SE
American journal of physiology. Lung cellular and molecular physiology 20140321 9
Sialic acids on glycoconjugates play a pivotal role in many biological processes. In the airways, sialylated glycoproteins and glycolipids are strategically positioned on the plasma membranes of epithelia to regulate receptor-ligand, cell-cell, and host-pathogen interactions at the molecular level. We now demonstrate, for the first time, sialidase activity for ganglioside substrates in human airway epithelia. Of the four known mammalian sialidases, NEU3 has a substrate preference for ganglioside ...[more]