Ontology highlight
ABSTRACT:
SUBMITTER: Descatoire M
PROVIDER: S-EPMC4010902 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20140414 5
Mouse splenic marginal zone precursors (MZPs) differentiate into marginal zone B (MZB) cells under a signaling pathway involving Notch2 and its ligand, delta-like 1 ligand (Dll1). We report the identification of an MZP subset in the spleen of young children. These MZPs differentiate into MZ-like B cells in vitro in the presence of OP9 cells expressing human DLL1, as demonstrated by the up-regulation of classical MZB cell markers. A set of diagnostic genes discriminating IgM(+)IgD(+)CD27(+) blood ...[more]