Unknown

Dataset Information

0

Constitutive expression of the AP-1 transcription factors c-jun, junD, junB, and c-fos and the marginal zone B-cell transcription factor Notch2 in splenic marginal zone lymphoma.


ABSTRACT: Splenic marginal zone lymphoma (SMZL) is a lymphoma type of putative marginal zone B-cell origin. No specific genetic alterations have yet been demonstrated in SMZL. Clinically, SMZL is a low-grade B-cell non-Hodgkin lymphoma. However, the presence of p53 mutation, 7q22-7q32 deletion or the absence of somatic hypermutations of immunoglobulin genes has been correlated with a worse prognosis. In this study, we analyzed genome-wide gene expression of 24 cases of SMZL using the microarray technique. The AP-1 transcription factors c-jun, junD, junB, and c-fos as well as Notch2 were found to be specifically up-regulated. These data were confirmed by real-time PCR and immunohistochemical staining of tissue sections. The absence of concordant high expression of the MAP kinases, the signaling cascade leading to AP-1 up-regulation, suggests autoregulation of the AP-1 transcription factors and an important role in SMZL oncogenesis. High expression of Notch2, a transcription factor that induces marginal zone B-cell differentiation, is highly suggestive for a marginal zone B-cell origin of SMZL. In addition, SMZL with the 7q deletion showed high expression of TGF-beta1 and low expression of the DNA helicase XPB, a crucial part of the nucleotide excision repair complex, possibly explaining the more aggressive clinical course of those cases.

SUBMITTER: Troen G 

PROVIDER: S-EPMC1867488 | biostudies-literature | 2004 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications

Constitutive expression of the AP-1 transcription factors c-jun, junD, junB, and c-fos and the marginal zone B-cell transcription factor Notch2 in splenic marginal zone lymphoma.

Trøen Gunhild G   Nygaard Vigdis V   Jenssen Tor-Kristian TK   Ikonomou Ida Münster IM   Tierens Anne A   Matutes Estella E   Gruszka-Westwood Alicja A   Catovsky Daniel D   Myklebost Ola O   Lauritzsen Grete G   Hovig Eivind E   Delabie Jan J  

The Journal of molecular diagnostics : JMD 20041101 4


Splenic marginal zone lymphoma (SMZL) is a lymphoma type of putative marginal zone B-cell origin. No specific genetic alterations have yet been demonstrated in SMZL. Clinically, SMZL is a low-grade B-cell non-Hodgkin lymphoma. However, the presence of p53 mutation, 7q22-7q32 deletion or the absence of somatic hypermutations of immunoglobulin genes has been correlated with a worse prognosis. In this study, we analyzed genome-wide gene expression of 24 cases of SMZL using the microarray technique.  ...[more]

Similar Datasets

| S-EPMC3428941 | biostudies-literature
| S-EPMC3428949 | biostudies-literature
| S-EPMC4010902 | biostudies-literature
2014-03-26 | E-MTAB-2244 | biostudies-arrayexpress
| S-EPMC8410048 | biostudies-literature
| S-EPMC8329169 | biostudies-literature
2015-04-23 | PXD001124 | Pride
| S-EPMC7889629 | biostudies-literature
| S-EPMC6639539 | biostudies-literature