Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC4011590 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Li Jie J Zhu Shan S Kozono David D Ng Kimberly K Futalan Diahnn D Shen Ying Y Akers Johnny C JC Steed Tyler T Kushwaha Deepa D Schlabach Michael M Carter Bob S BS Kwon Chang-Hyuk CH Furnari Frank F Cavenee Webster W Elledge Stephen S Chen Clark C CC
Oncotarget 20140201 4
Glioblastoma remains one of the deadliest of human cancers, with most patients succumbing to the disease within two years of diagnosis. The available data suggest that simultaneous inactivation of critical nodes within the glioblastoma molecular circuitry will be required for meaningful clinical efficacy. We conducted parallel genome-wide shRNA screens to identify such nodes and uncovered a number of G-Protein Coupled Receptor (GPCR) neurotransmitter pathways, including the Dopamine Receptor D2 ...[more]