Ontology highlight
ABSTRACT:
SUBMITTER: Clarke TK
PROVIDER: S-EPMC4013426 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Clarke Toni-Kim TK Weiss Amy R D AR Ferarro Thomas N TN Kampman Kyle M KM Dackis Charles A CA Pettinati Helen M HM O'brien Charles P CP Oslin David W DW Lohoff Falk W FW Berrettini Wade H WH
Annals of human genetics 20131125 1
The risk for drug addiction is partially heritable. Genes of the dopamine system are likely candidates to harbour risk variants, as dopamine neurotransmission is involved in mediating the rewarding effects of drugs of abuse. One functional single nucleotide polymorphism in dopamine receptor D2 (DRD2), rs1076560, is involved in regulating splicing of the gene and alters the ratio of DRD2 isoforms located pre- and postsynaptically. rs1076560 has been previously associated with cocaine abuse and we ...[more]