Ontology highlight
ABSTRACT:
SUBMITTER: Jiang X
PROVIDER: S-EPMC4011640 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Jiang Xinguo X Malkovskiy Andrey V AV Tian Wen W Sung Yon K YK Sun Wenchao W Hsu Joe L JL Manickam Sathish S Wagh Dhananjay D Joubert Lydia-Marie LM Semenza Gregg L GL Rajadas Jayakumar J Nicolls Mark R MR
Biomaterials 20131022 2
Airway tissue ischemia and hypoxia in human lung transplantation is a consequence of the sacrifice of the bronchial circulation during the surgical procedure and is a major risk factor for the development of airway anastomotic complications. Augmented expression of hypoxia-inducible factor (HIF)-1α promotes microvascular repair and alleviates allograft ischemia and hypoxia. Deferoxamine mesylate (DFO) is an FDA-approved iron chelator which has been shown to upregulate cellular HIF-1α. Here, we d ...[more]