Ontology highlight
ABSTRACT:
SUBMITTER: Acharya AP
PROVIDER: S-EPMC4011665 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Chemical communications (Cambridge, England) 20131101 88
The low detection sensitivity of enzyme linked immunosorbent assays (ELISAs) is a central problem in science and limits progress in multiple areas of biology and medicine. In this report we demonstrate that the hydrocyanines, a family of fluorescent reactive oxygen species (ROS) probes, can act as turn on fluorescent horseradish peroxidase (HRP) probes and thereby increase the sensitivity of conventional ELISAs by two orders of magnitude. ...[more]