Ontology highlight
ABSTRACT:
SUBMITTER: Sattler S
PROVIDER: S-EPMC4012142 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Sattler Susanne S Ling Guang-Sheng GS Xu Damo D Hussaarts Leonie L Romaine Andreas A Zhao Hongzhi H Fossati-Jimack Liliane L Malik Talat T Cook H Terence HT Botto Marina M Lau Yu-Lung YL Smits Hermelijn H HH Liew Foo Y FY Huang Fang-Ping FP
Journal of autoimmunity 20140201
Regulatory B cells (Breg) have attracted increasing attention for their roles in maintaining peripheral tolerance. Interleukin 33 (IL-33) is a recently identified IL-1 family member, which leads a double-life with both pro- and anti-inflammatory properties. We report here that peritoneal injection of IL-33 exacerbated inflammatory bowel disease in IL-10-deficient (IL-10(-/-)) mice, whereas IL-33-treated IL-10-sufficient (wild type) mice were protected from the disease induction. A phenotypically ...[more]