Ontology highlight
ABSTRACT:
SUBMITTER: Palacios G
PROVIDER: S-EPMC4012429 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Palacios Gustavo G Talos Flaminia F Nemajerova Alice A Moll Ute M UM Petrenko Oleksi O
Cell cycle (Georgetown, Tex.) 20080630 12
To better understand the role of E2F1 in tumor formation, we analyzed spontaneous tumorigenesis in p53(-/-)E2F1(+/+) and p53(-/-)E2F1(-/-) mice. We show that the combined loss of p53 and E2F1 leads to an increased incidence of sarcomas and carcinomas compared to the loss of p53 alone. E2F1-deficient tumors show wide chromosomal variation, indicative of genomic instability. Consistent with this, p53(-/-)E2F1(-/-) primary fibroblasts have a reduced capacity to maintain genomic stability when expos ...[more]